The COVID-19 pandemic had significant impacts on various aspects of life, prompting researchers to explore new avenues of hope using unconventional resources. Biosurfactants, sustainable biomolecules with unique properties and versatile applications, have drawn attention. Among various bacterial species, Bacillus species have demonstrated high biosurfactant activity, with Bacillus subtilis being notable. Recent studies have confirmed the antiviral, antimicrobial, and anti-inflammatory properties of B. subtilis, which is non-toxic. When triggered by biosurfactant bacteria, pro-inflammatory cytokines are secreted at higher levels from neutrophils and monocytes. This suggests the potential application of B. subtilis and its biomolecules against COVID-19, possibly in the form of a vaccine or therapeutic agent, contributing to a greener environment, healthier life, and environmental sustainability. However, further, in vivo and clinical trials are required to validate this hypothesis.
Reference: Potential of Bacillus subtilis Against SARS-CoV-2 – A Sustainable Drug Development Perspective
